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5-amino-1mq
🔬 What Is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase).
NNMT is an enzyme that breaks down NAD⁺ precursors and influences energy metabolism.
By inhibiting NNMT, 5-Amino-1MQ is thought to increase NAD⁺ availability, enhance cellular metabolism, and promote fat breakdown.
⚙️ Mechanism of Action
Blocks NNMT activity → reduces methylation of nicotinamide.
Preserves nicotinamide for conversion into NAD⁺ → boosts mitochondrial function and cellular energy.
Alters fat cell (adipocyte) metabolism → reduces size of fat cells and enhances lipolysis.
May influence insulin sensitivity, inflammation, and metabolic rate.
📊 Research Findings (Mostly Preclinical)
Obesity models (mice): 5-Amino-1MQ reduced body weight and fat mass, even without major dietary changes.
Muscle & metabolism: improved energy utilization and insulin sensitivity in preclinical studies.
Neuroprotection: some evidence suggests it may protect against cognitive decline by preserving NAD⁺ levels.
⚠️ Human clinical trials are lacking—most data comes from cell and animal studies.
💉 Dosing (Research/Clinic Use)
Since it’s not FDA-approved, dosing protocols vary:
Oral (capsules): 25–50 mg daily is often seen in compounding/wellness clinics.
Cycles: Sometimes used for 4–8 weeks, then paused.
Formulations: Oral capsules are most common, but injectable forms have been explored in research.
⚠️ There are no standardized, evidence-based dosing guidelines—all human use is experimental.
⚠️ Safety & Side Effects
Preclinical data suggests it is generally well tolerated.
Reported in wellness settings: mild headache, jitteriness, or stomach upset.
Long-term human safety data does not exist.
Unknown effects on methylation balance (since NNMT inhibition changes one-carbon metabolism).
✅ Key Takeaways
5-Amino-1MQ = investigational NNMT inhibitor that boosts NAD⁺ and may promote fat loss & metabolic health.
Potential benefits: fat reduction, metabolic improvement, insulin sensitivity, anti-aging.
Status: promising but still experimental, with no FDA approval or large-scale human studies.
Use: Often compounded as oral capsules, typically 25–50 mg daily in research/clinic settings.
🔬 What Is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase).
NNMT is an enzyme that breaks down NAD⁺ precursors and influences energy metabolism.
By inhibiting NNMT, 5-Amino-1MQ is thought to increase NAD⁺ availability, enhance cellular metabolism, and promote fat breakdown.
⚙️ Mechanism of Action
Blocks NNMT activity → reduces methylation of nicotinamide.
Preserves nicotinamide for conversion into NAD⁺ → boosts mitochondrial function and cellular energy.
Alters fat cell (adipocyte) metabolism → reduces size of fat cells and enhances lipolysis.
May influence insulin sensitivity, inflammation, and metabolic rate.
📊 Research Findings (Mostly Preclinical)
Obesity models (mice): 5-Amino-1MQ reduced body weight and fat mass, even without major dietary changes.
Muscle & metabolism: improved energy utilization and insulin sensitivity in preclinical studies.
Neuroprotection: some evidence suggests it may protect against cognitive decline by preserving NAD⁺ levels.
⚠️ Human clinical trials are lacking—most data comes from cell and animal studies.
💉 Dosing (Research/Clinic Use)
Since it’s not FDA-approved, dosing protocols vary:
Oral (capsules): 25–50 mg daily is often seen in compounding/wellness clinics.
Cycles: Sometimes used for 4–8 weeks, then paused.
Formulations: Oral capsules are most common, but injectable forms have been explored in research.
⚠️ There are no standardized, evidence-based dosing guidelines—all human use is experimental.
⚠️ Safety & Side Effects
Preclinical data suggests it is generally well tolerated.
Reported in wellness settings: mild headache, jitteriness, or stomach upset.
Long-term human safety data does not exist.
Unknown effects on methylation balance (since NNMT inhibition changes one-carbon metabolism).
✅ Key Takeaways
5-Amino-1MQ = investigational NNMT inhibitor that boosts NAD⁺ and may promote fat loss & metabolic health.
Potential benefits: fat reduction, metabolic improvement, insulin sensitivity, anti-aging.
Status: promising but still experimental, with no FDA approval or large-scale human studies.
Use: Often compounded as oral capsules, typically 25–50 mg daily in research/clinic settings.