PT-141 10mg

🔬 What Is PT-141?

• PT-141 (generic name bremelanotide) is a synthetic peptide derived from Melanotan II.

• Unlike Viagra or Cialis (which work on blood flow), PT-141 acts in the brain by stimulating melanocortin receptors (MC3R & MC4R) that regulate sexual arousal.

• It does not require sexual stimulation to be effective.

📌 FDA Status

• Approved in the U.S. as Vyleesi (2019).

• Indication: Premenopausal women with hypoactive sexual desire disorder (HSDD).

• Also used off-label for men with erectile dysfunction (ED), especially when PDE-5 inhibitors (Viagra, Cialis) don’t work.

⚙️ Mechanism of Action

• Activates melanocortin receptors in the hypothalamus, enhancing sexual desire and arousal pathways.

• In men, this translates into improved erectile function, and in women, enhanced libido and satisfaction.

• Effects begin in 30–60 minutes and can last 6–12 hours, sometimes longer.

⚠️ Side Effects

Most common:

• Nausea (up to 40%)

• Flushing

• Headache

• Injection site reactions

Other considerations:

• Can cause a temporary increase in blood pressure and reduction in heart rate. Not recommended for those with uncontrolled hypertension or cardiovascular disease.

• Some users experience darkening of moles or skin with repeated use (due to melanocortin receptor activity).

✅ Key Takeaways

• PT-141 = Bremelanotide, a melanocortin receptor agonist.

• Main effect: Increases sexual desire/arousal (women) and erectile function (men, off-label).

• Dose: Typically 1.75 mg SC (FDA) or 0.5–2 mg SC (clinic use).

• Side effects: Nausea, flushing, temporary BP changes.

• Unique: Works centrally in the brain—not via blood vessels like Viagra.