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SS-31, also known as Elamipretide, Bendavia, or MTP-131, is a synthetic tetrapeptide (sequence: D-Arg-Dmt-Lys-Phe-NH₂) that selectively targets mitochondria by binding to cardiolipin, a critical lipid in the inner mitochondrial membrane.
It enhances electron transport, stabilizes mitochondrial supercomplexes, preserves ATP production, and reduces reactive oxygen species (ROS) by modulating the cytochrome c–cardiolipin interaction and preventing mitochondrial permeability transition pore opening.
The International Peptide SocietyPeptide SciencesWikipedia
Mitochondrial support: Rapidly restores energy production in aging muscle and enhances endurance.
Peptide SciencesPMC
Neurovascular protection: Improves blood flow and cognitive performance in aged animal models.
PubMed
Neurological and systemic resilience: Provides neuroprotection in models of brain injury, reduces oxidative stress and apoptosis, and supports synaptic integrity.
Alzheimer's Drug Discovery FoundationBioMed Central
Rare diseases: Demonstrated efficacy in Barth syndrome and mitochondrial disorders by improving cardiac and mitochondrial function.
Alzheimer's Drug Discovery FoundationNatureWikipedia
Other potential effects: Preclinical benefits observed in protecting against diabetic nephropathy, atherosclerosis, pulmonary hypertension, and muscle aging.
Alzheimer's Drug Discovery FoundationPeptide Sciences
SS-31, also known as Elamipretide, Bendavia, or MTP-131, is a synthetic tetrapeptide (sequence: D-Arg-Dmt-Lys-Phe-NH₂) that selectively targets mitochondria by binding to cardiolipin, a critical lipid in the inner mitochondrial membrane.
It enhances electron transport, stabilizes mitochondrial supercomplexes, preserves ATP production, and reduces reactive oxygen species (ROS) by modulating the cytochrome c–cardiolipin interaction and preventing mitochondrial permeability transition pore opening.
The International Peptide SocietyPeptide SciencesWikipedia
Mitochondrial support: Rapidly restores energy production in aging muscle and enhances endurance.
Peptide SciencesPMC
Neurovascular protection: Improves blood flow and cognitive performance in aged animal models.
PubMed
Neurological and systemic resilience: Provides neuroprotection in models of brain injury, reduces oxidative stress and apoptosis, and supports synaptic integrity.
Alzheimer's Drug Discovery FoundationBioMed Central
Rare diseases: Demonstrated efficacy in Barth syndrome and mitochondrial disorders by improving cardiac and mitochondrial function.
Alzheimer's Drug Discovery FoundationNatureWikipedia
Other potential effects: Preclinical benefits observed in protecting against diabetic nephropathy, atherosclerosis, pulmonary hypertension, and muscle aging.
Alzheimer's Drug Discovery FoundationPeptide Sciences