Thymosin Alpha-1

$50.00

🔬 What Is Thymosin Alpha-1?

  • Thymosin Alpha-1 is a 28-amino acid peptide originally isolated from thymosin fraction 5, a thymus extract.

  • It is naturally produced in the thymus gland, where it helps regulate immune function.

  • The synthetic form (thymalfasin) is used as an immunomodulatory agent in many countries, though it is not FDA-approved in the U.S. (except under certain compassionate or investigational uses).

⚙️ Mechanism of Action

  • Enhances T-cell maturation and differentiation.

  • Boosts dendritic cell activity → improves antigen presentation.

  • Increases natural killer (NK) cell activity.

  • Modulates cytokine production (increasing IFN-α, IL-2; reducing pro-inflammatory signals).

  • Helps restore balance between Th1 and Th2 immunity.

In short, it fine-tunes both innate and adaptive immunity.

📌 Clinical & Research Uses

Thymosin Alpha-1 has been studied for:

  • Chronic viral infections: Hepatitis B & C, HIV

  • Cancer (as an immune adjuvant alongside chemotherapy or vaccines)

  • Immunodeficiency states (primary or acquired)

  • Sepsis and severe infections (shown to reduce mortality in some trials)

  • COVID-19 (studied during the pandemic for immune modulation in severe cases)

  • Vaccine adjuvant (improves vaccine response, especially in the elderly and immunocompromised)

⚠️ Safety & Side Effects

  • Generally well tolerated.

  • Reported side effects: mild injection site reactions, transient fatigue, headache, or flu-like symptoms.

  • No major toxicities documented even with long-term use.

  • Contraindications: avoid in patients with active organ transplantation (may alter immune balance).

✅ Key Takeaways

  • Thymosin Alpha-1 = naturally occurring thymic peptide, powerful immune system modulator.

  • Uses: chronic viral infections, immune deficiency, cancer support, sepsis, and as a vaccine adjuvant.

  • Dose: usually 1.6–2 mg SC 2–3x per week, scaled higher in specific protocols.

  • Status: Approved in >35 countries (e.g., Italy, China) but not FDA-approved in the U.S. outside investigational use.

  • Safety: Well tolerated with minimal side effects in studies.

🔬 What Is Thymosin Alpha-1?

  • Thymosin Alpha-1 is a 28-amino acid peptide originally isolated from thymosin fraction 5, a thymus extract.

  • It is naturally produced in the thymus gland, where it helps regulate immune function.

  • The synthetic form (thymalfasin) is used as an immunomodulatory agent in many countries, though it is not FDA-approved in the U.S. (except under certain compassionate or investigational uses).

⚙️ Mechanism of Action

  • Enhances T-cell maturation and differentiation.

  • Boosts dendritic cell activity → improves antigen presentation.

  • Increases natural killer (NK) cell activity.

  • Modulates cytokine production (increasing IFN-α, IL-2; reducing pro-inflammatory signals).

  • Helps restore balance between Th1 and Th2 immunity.

In short, it fine-tunes both innate and adaptive immunity.

📌 Clinical & Research Uses

Thymosin Alpha-1 has been studied for:

  • Chronic viral infections: Hepatitis B & C, HIV

  • Cancer (as an immune adjuvant alongside chemotherapy or vaccines)

  • Immunodeficiency states (primary or acquired)

  • Sepsis and severe infections (shown to reduce mortality in some trials)

  • COVID-19 (studied during the pandemic for immune modulation in severe cases)

  • Vaccine adjuvant (improves vaccine response, especially in the elderly and immunocompromised)

⚠️ Safety & Side Effects

  • Generally well tolerated.

  • Reported side effects: mild injection site reactions, transient fatigue, headache, or flu-like symptoms.

  • No major toxicities documented even with long-term use.

  • Contraindications: avoid in patients with active organ transplantation (may alter immune balance).

✅ Key Takeaways

  • Thymosin Alpha-1 = naturally occurring thymic peptide, powerful immune system modulator.

  • Uses: chronic viral infections, immune deficiency, cancer support, sepsis, and as a vaccine adjuvant.

  • Dose: usually 1.6–2 mg SC 2–3x per week, scaled higher in specific protocols.

  • Status: Approved in >35 countries (e.g., Italy, China) but not FDA-approved in the U.S. outside investigational use.

  • Safety: Well tolerated with minimal side effects in studies.